Chemical Aspects of Lithium Mediation of Nitric Oxide Levels in Serum Protein Models
نویسندگان
چکیده
Print ISSN 0974-0678, Online : 2320-9593, www.bionanofrontier.org ABSTRACT: The importance of nitric oxide (NO) in biological systems is very well established. It is known to play a vital role in functions of the nervous, circulatory, respiratory, defense and reproductive systems and also to act as an important signaling molecule. Lithium salts are widely used in the treatment of a range of mental illnesses from mood disorders to schizophrenia. Injections of lithium chloride showed a four-fold increase in nitric oxide levels in chick embryos. We were therefore interested in the effect of NO and lithium both individually and jointly on the Coomassie Brilliant Blue (CBB) and bovine serum albumin (BSA) interaction model studied earlier in our laboratory. Spectrophotometric studies of these interactions in terms of binding parameters are presented. Our findings support the earlier observations of lithium chloride leading to an up regulation of nitric oxide levels.
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